Diouf had been receiving treatment in his home country, Senegal, before passing away, the Senegalese President Macky Sall confirmed.
“We send our sincerest condolences to his family and loved ones.”
Diouf was Marseille’s president from 2005 to 2009. He was the first black president of a major European club.
Before that he was a journalist and player agent, representing the likes of Marcel Desailly, Samir Nasri and Didier Drogba.
“A member of the LFP administrative council from September 2007 to June 2009, Pape Diouf will be remembered as a charismatic and passionate director.
“In this moment of immense sadness for French football, the LFP offers its condolences to his family and those close to him, and to Olympique de Marseille.”
During Diouf’s tenure, Marseille twice finished Ligue 1 runners-up and were finalists in two French Cups.
‘A great man’
The year after his departure, the club won the league with many of the players he helped to sign playing key roles.
“When Pape calls me and says ‘I only have one word, we agreed on your signature at OM, and your injury won’t change (my mind) what I think of your quality and the fact that you’re a player made to wear the color of your club at heart that’s Olympic de Marseille.’ Deep respect for this man.”
Nasri, who left Marseille to join Arsenal in 2008, spoke of the effect Diouf had on his blossoming career.
“You have always been a mentor, you have been my first agent, you were my president. And it is with a heavy heart that I must say goodbye. You left too early. I will never forget you, Pape Diouf.”